Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Effect of Preanesthetic Medication of Intravenous Medetomidine in Dogs
Kazuto YAMASHITATetsuya TYUMAYasuharu IZUMISAWATadao KOTANI
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JOURNAL FREE ACCESS

1998 Volume 51 Issue 2 Pages 85-90

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Abstract

For evaluation of medetomidine as a preanesthetic medicaion, 21 dogs each were injected intravenously with 0.05 mg/kg atropine plus 0.25 mg/kg droperidol, 5 or 10 μg/kg medetomidine. In all cases, anesthesia was induced by intravenous injection of 5 mg/kg ketamine, followed by intratracheal intubation and anesthetization by nitrous oxide-oxygen-isoflurane or -sevoflurane. The adequate sedative effect and muscular relaxation were induced by 5 μg/kg medetomidine, and the heart rate around 110 bpm and peripheral blood pressure were maintained during surgery, although bradycardia was observed immediately after injection of medetomidine. With premedication of 10 μg/kg medetomidine, vomiting and apnea were notable after intubation, while the end-expiratory concentrations of isoflurane and sevoflurane during surgery were lowest.

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