2001 Volume 54 Issue 11 Pages 843-846
Turbidity of the cornea, in newborn puppies a mechanism for protecting the immature retinaand tapetum, parallels decrease in the density of the matrix and thickening and aligning of collagen fibrils. Biochemical analysis indicates a considerable increase in keratan sulfate and a decrease in dermatan sulfate during cornea development. Maintenance of collagen-fibril diameter and preservation of interstitial spaces seems to depend on the functioningof keratan sulfate. Dermatan, on the other hand, inhibits formation of collagen fibrils.Observation of these samples suggests that these two ground substances play essential roles in corneal maturation in neonatal dogs.