Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Interstitial α-Smooth Muscle Actin Expression as a Marker Predicting Prognosis of Chronic Renal Failure in Cats
Ko SAWASHIMAYuko SAWASHIMAHidetoshi SHITAKATadaaki KUDOTsutomu KUROSAWA
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2002 Volume 55 Issue 4 Pages 225-229

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Abstract

In assessing the expression of α-smooth muscle actin (α-SMA) in the renal stroma as a marker for predicting prognosis in cats with chronic renal failure (CRF), we analyzed 14 specimens collected by means of percutaneous renal biopsy. Correlation was good (r2=0.619, P<0.001) between the a-SMA expression and the progression rate of renal failure calculated from linear regression using the reciprocal of serum-creatinine concentration (sCr) versus time. After one year of follow-up, correlation between initial sCr and interstitial a-SMA arrived at by multiple linear regression analysis was significant (contribution ratio= 92%, P<0.001). These findings indicate that interstitial a-SMA expression rate is a good marker for predicting prognosis of spontaneous feline CRF.

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