Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Primary Macroglobulinemia in a Dog
Tetsuya SHIMODATadahisa MASHITATakuya MATSUKAWATakatsugu YAMADAAtsuhiko HASEGAWA
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2002 Volume 55 Issue 4 Pages 231-234

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Abstract

A 1-year-old Male miniature Dachshund was admitted to the Sanyo Animal Medical Center because of diarrhea and weight loss. Initial physical examination revealed slightly pale mucous membranes and slightly enlarged superficial lymph nodes. Ophthalmic examination revealed mild dilation of the retinal veins. Hematologic and serum biochemical abnormalities included anemia, thrombocytopenia, and hyperproteinemia with monoclonal gammopathy. Abdominal radiographs revealed hepatomegaly and splenomegaly. Serum immunoelectrophoresis showed an abnormal band consisting of IgM. Urine-protein electrophoresis demonstrated a monoclonal spike in the gamma region. Urine SDS-polyacryl-amide gel electrophoresis identified Bence Jones protein uria. On the basis of these findings, we diagnosed macroglobulinemia. On the 12th day of the illness, the dog died of pulmonary hemorrhage.

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