Chromosome Abnormality in Porcine Lymphosarcoma Blood

Abstract

Blood examinations (leukocyte count and differential leukocyte count in percentages) and chromosome examinations (culture method and direct-preparation method) were conducted on whole blood (living blood and/or post-slaughter remainder blood) of the multi-centric type (16), the alimentary type (8), and the thymic type (1), all of which had been diagnosed as porcine lymphosarcoma. Blood examinations revealed atypical lymphocytes in 8 cases. Chromosome examinations revealed chromosome abnormalities in 11 cases (9 of the multi-centric type and 2 of the alimentary type). The multi-centric types were classified as non-clonal abnormalities (2) or clonal abnormalities (7). The alimentary types were classified as non-clonal (1) and clonal (1). In the case of clonal abnormalities, when both numerous lymphosarcoma cells flow in from physiologically broken tumor tissues and cells flow out from unbroken tumor tissues, a precise diagnosis of leukemia is possible.