Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Hepatic Encephalopathy Associated with Severe Fatty Liver in a Post-parturient Cow
Takashi TAMURAYukio M. SEIMIYAMaki TAKAHASHIRyukoh MURAKAMI
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2003 Volume 56 Issue 9 Pages 587-591

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Abstract

Biochemical and pathological examinations were made of a 4-year-old Holstein-Friesian cow that had been significantly obese during the late-and non-lactating periods and had demonstrated such clinical abnormalities as anorexia, depression, and unsteady gait since the pre-parturition stage. Sera analyses disclosed markedly increased NEFA concentration from 19 days prepartum (d pre) to 70 days postpartum (d post) and severely decreased apoB-100 from 12 d pre to 20 d post. Elevated enzyme-activity levels were found in AST, LDH, LDH isozyme 1-3, and GGT from 1 d pre to 20 d post. Macroscopically, the liver showed hardening and an obvious lobular architecture on the cut surface. Histologically, central nervoussystem (CNS) lesions were characterized by spongy degeneration in the white matter and altered astrocytes in the gray matter. Pronounced former lesions appeared in the corpus striatum, diencephalon, and mesencephalon. Severe fatty degeneration of the hepatocytes accompanying fibrosis was observed. An extended period of severe hepatocellular fatty degeneration appeared to cause the CNS lesions.

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