犬のリンパ球性プラズマ細胞性膝関節炎における血中活性型TGF-β1の増加

桑原 正人; 成相 陽子; 山口 優; 永岡 勝好; 大場 茂夫; 鎌田 寛; 湯川 眞嘉

doi:10.12935/jvma1951.57.521

Increase of Activated TGF-β1 in the Blood of canine Lymphocytic- plasmacytic Gonarthritis

Masato KUWABARA, Youko NARIAI, Yu YAMAGUCHI, Katsuyoshi NAGAOKA, Shigeo OHBA, Hiroshi KAMATA, Masayoshi YUKAWA

Author information

Keywords: activated TGF -β1, lymphocytic-plasmacytic gonarthritis, Th3 response

JOURNAL FREE ACCESS

2004 Volume 57 Issue 8 Pages 521-524

DOI https://doi.org/10.12935/jvma1951.57.521

Details

Abstract

Immunological examination of two dogs (flat-coated retrievers) diagnosed as lymphocytic- plasmacytic gonarthritis revealed a T-cell subset imbalance in the knee joints and increased activity of transforming- growth factor-β1 (TGF-β1) as a Th3 cytokine. This finding suggests that immune abnormality mediated by TGF-β1 may play a part in the development of this disease.

Corresponding author

Register with J-STAGE for free!