Preventive Effects of Bacillus subtilis DB9011 Administration on Post-Surgical Cell-Mediated Immunosuppression in Dogs

Abstract

The preventive effects of Bacillus subtilis DB9011 (DB9011) on the immunosuppression induced by anesthesia and surgery were investigated in dogs. DB9011 was administered before andafter operation, and a chemiluminescence (CL) assay of the canine neutrophils, macrophagesand peripheral blood lymphocytes (PBL) was performed. In dogs receiving DB9011, CL activity of macrophages and PBL showed a significant increase from one day post-operation compared to that in dogs without the administration of DB9011. Especially, PBL activity was maintained with a more significant increase. These results suggest that daily administration of DB9011 before and after operation may prevent immunosuppression at the earlier phase of the postsurgical period.