Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Long-term Management of Plasma Glucose Concentration by a Single Administration of Streptozocin in a Dog with Insulinoma
Masashi YUKIKiyomi SUZUKISakiko TANAHASHIMayuko KATOHTakashi HIRANOMasaki TAKAHASHIAtsuko MURAITakeshi SAKAGUCHI
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2007 Volume 60 Issue 12 Pages 867-871

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Abstract

A 10-year-old bitch, a golden retriever, with exercise intolerance underwent various medical examinations. Consequently, insulinoma was suspected. An exploratory celiotomy was performed for a definite diagnosis. Then, a tumor was observed in the pancreas, and a surgical resection was performed. It was diagnosed as insulinoma by pathological examination. The post operative course was favorable without treatment, but hypoglycemia was observed about a month after the operation. The dog was initially treated with prednisolonebased therapy, and although the blood glucose level became controllable for about two months, it became impossible after that time. Then, when streptozotocin was administered, the blood glucose level recovered to normal levels. Finally, for approximately six months until death from hemangiosarcoma, which developed during insulinoma treatment, the blood glucose was at a normal level without additional medication with streptozotocin.

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