Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Efficacy and Safety of Japanese Rabies Vaccine (Inactivated) in Dogs According to the Injection Method Mandated the Import-Export Quarantine Regulation for Dogs and Other Animals
Shinsuke EZOETakashi OHMORIKo-ichi KUSANAGIHiromi YASUDAMorimasa YAMANAKAKazue SAIJONoriyasu TAKIKAWAKen-ichi AMANO
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2007 Volume 60 Issue 12 Pages 873-878

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Abstract

The efficacy and safety of Japanese rabies vaccine (inactivated) for veterinary use were investigated in dogs inoculated twice, as mandated by the Import-Export Quarantine Regulation for Dogs and Other Animals. The potency of these vaccines was 1.7-6.2IU/ml based on the National Institute of Health test. These values were more than the 1.0IU/ml potency recommended by OIE. A strong correlation (r=0.927) was found between the results of the fluorescent antibody virus neutralization (FAVN) test and those of the virus neutralization (VN) test. It was considered that the FAVN titer of 0.5IU/ml recommended by the Quarantine Regulations corresponded to a VN titer of 25. After two injections with a one month interval between them, the dogs had a VN titer of 1, 655 one month after the second injection and a VN titer of 176 one year after the second injec -tion. Moreover, after two injections with a one year interval between them, the VN titer increased to 3, 096 at one month after the second injection. There were no adverse reactions following vaccinations of dogs inject-ed once with five doses and three times with ten doses. Consequently, two vaccination methods for dogs with Japanese rabies vaccine as provided by the Quarantine Regulations were considered safe and effective.

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