Abstract
This paper is the first report of a horse with multisystemic eosinophilic epitheliotropic disease in Japan. A two-year-old male thoroughbred was admitted with anorexia and colic. The horse showed a remarkable increase in γ GTP, slight hypoproteinemia, hypoalbuminemia, and a lack of peripheral eosinophilia. The symptoms were not resolved with medical therapy. Exploratory laparotomy was performed, and a wall thickening and inflammation of theserous membrane on the small intestine were found. The horse was euthanatized with the diagnosis of perforation of the gastric ulcer two days after the laparotomy. White nodules were found in the pancreas at necropsy. Histopathologically, eosinophilic and lymphocytic infiltration as well as fibrosis were identified in the pancreas, liver, small intestine andlymph nodes (porta hepatic and mesenteric). The white nodules in the pancreas were eosinophilic granuloma. This case was histopathologically diagnosed as multisystemic eosinophilic epitheliotropic disease.
