Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Molecular Epidemiological Analysis of Bovine Ephemeral Fever Virus Isolated in Okinawa Prefecture
Maki AIZAWAKatsunori TAKAYOSHITamotsu KOKUBATomoko KATOToru YANASEMakoto YAMAKAWATomoyuki TSUDA
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2008 Volume 61 Issue 5 Pages 363-366

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Abstract

To define the epidemiology of Bovine Ephemeral Fever (BEF) in Okinawa prefecture, the glycoprotein geneof ten Okinawan BEF virus isolates between 1988 and 2004 were sequenced and subjected to phylogeneticalanalysis with other available BEF viruses. Phylogenetical analysis revealed that the Okinawan and Taiwaneseisolates formed a monophyletic group that was separated from the vaccine (YHL) strain and the Australian isolatesand were further divided into two clusters, those isolated in the 1980s and those isolated in the 1990 and2000s. High nucleotide identities were observed between the Okinawan and Taiwanese isolates in the sameyear, indicating an epidemiological link between the BEF outbreaks in Okinawa prefecture and those in Taiwan. Although four amino acid substitutions in the neutralizing epitopes of the glycoprotein were foundbetween the YHL strain and Okinawan isolates, immune serum from vaccinated cattle equally neutralized boththe Okinawan isolates and the YHL stra in in the neutralization test.

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