Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
A Polymorphism Observed in the Experimentally Successful Peptide Vaccine Sequence Derived from Theileria sergenti Piroplasm Major Surface Antigen (p33)
Shin-Ichiro KAWAZUToshinari OKUMURAYasuhiro HIROGARITokuji MIYAHARAYouichiro TERASAKAMotonobu HIDAYutaka TERADATsugihiko KAMIOKozo FUJISAKI
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1997 Volume 59 Issue 9 Pages 829-831

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Abstract

A polymorphism in the experimentally successful peptide vaccine sequence (EVVWKEKKEVKDLDA, amino acids 134-148) derived from the 33 kDa piroplasm major surface antigen (p33) of Theileria sergenti was examined. The vaccine sequences obtained by PCR amplification and sequencing of the p33 gene from a total of 15 parasite-infected cattle blood samples collected from 4 prefectures through Hokkaido to Kumamoto revealed the two major sequences (Ikeda and Chitose stock types) either of which was identified in all samples. Since the peptide vaccine develops the parasite species- or stock-specific immunity in the animals, an application of the two major peptide sequences as cocktailed vaccine should be evaluated for a practical use of this strategy to controlling T. sergenti infection in Japan.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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