Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Effect of Recombinant Human Granulocyte Colony Stimulating Factor on Lymphocyte Blastogenesis in Healthy Dogs
Takashi HASEGAWATakateru INOMATA
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2000 Volume 62 Issue 11 Pages 1205-1207

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Abstract

Effects of recombinant human granulocyte colony−stimulating factor(rhG−CSF)on the number and blastogenesis of lymphocytes were evaluated in clinically healthy dogs treated subcutaneously with rhG−CSF at a dose of 2.5 μg/kg for 3 days.Significant increases in the number of leukocytes and segmented neutrophils were observed after the administration of rhG−CSF.The number of lymphocytes also increased on days 1 and 2 after the treatment.Activities of phytohemagglutinin, concanavalin A, and pokeweed mitogen−induced lymphocyte blastogenesis(LB)were augmented to twice the pretreatment levels by the administration of rhG−CSF.These results suggested that administration of rhG−CSF activated lymphocyte functions such as LB in healthy dogs.

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© 2000 by the Japanese Society of Veterinary Science

この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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