Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Atopic NC/Nga Mice as a Model for Allergic Asthma: Cytokine Profiles and Eosinophil Productivity of Bone Marrow
Tadashi IWASAKIAkane TANAKAHiroshi MATSUDAMisao ONUMA
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2001 Volume 63 Issue 4 Pages 471-474

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Abstract

In previous study, NC/Nga mice with experimentally induced asthma showed severe eosinophilia. To explore the mechanism, profiles of representative cytokines interleukin (IL)-4, IL-5, and interferon (IFN)-γ were examined in bronchoalveolar lavage fluid. The level of only IFN-γ was lower in NC/Nga mice than control BALB/c mice. Furthermore, bone marrow cell culture system under the presence of eosinopoietic cytokines, which induce the differentiation of progenitor cells into mature eosinophils, showed that a larger number of eosinophils differentiated from NC/Nga mice derived bone marrow cells than from control BALB/c mice. These results may imply the possibility that severe eosinophilia in the NC/Nga mice are attributable to lower production of IFN-γ and higher eosinophil productivity of bone marrow cells.

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© 2001 by the Japanese Society of Veterinary Science

この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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