Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Increased Plasma Levels of Soluble Intercellular Adhesion Molecule-1 (sICAM-1) and Soluble Vascular Cell Molecule-1 (sVCAM-1) Associated with Disease Severity in a Primate Model for Severe Human Malaria: Plasmodium coatneyi-Infected Japanese Macaques (Macaca fuscata)
Satoru KAWAIJun MATSUMOTOMasamichi AIKAWAHajime MATSUDA
著者情報
キーワード: Plasmodium coatneyi, sICAM-1, sVCAM-1
ジャーナル フリー

2003 年 65 巻 5 号 p. 629-631

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抄録

In the present study, we investigated plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) in seven Japanese macaques (Macaca fuscata) infected with Plasmodium coatneyi. Concentrations of sICAM-1 and sVCAM-1 were significantly elevated in the severe phase; the levels were maximally increased up to six times and three times those before infection, respectively. We subsequently examined kinetic profiles of sICAM-1 and sVCAM-1 concentration in plasma obtained from two infected monkeys. Both infected monkeys had markedly increased levels of these adhesion molecules when they exhibited severe clinical signs correlated with rapid increase in parasitemia. These results suggest that the elevation of levels of sICAM-1 and sVCAM-1 is a critical step in the pathogenesis of severe malaria in vivo.

著者関連情報
© 2003 by the Japanese Society of Veterinary Science

この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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