Cerebrospinal Fluid S-100B Concentrations in Normal and Diseased Cattle

抄録

We measured the concentrations of S-100B, a marker protein used in humans to detect brain damage, in the cerebrospinal fluid (CSF) of clinically normal cattle (n=15, mean age ± SD: 31.8 ± 37.5 months) and of cattle with various inflammatory disorders (n=43, 70.6 ± 31.9 months). The mean ± SD CSF S-100B level was 2.9 ± 1.6 ng/ml in the normal group and 7.0 ± 7.4 ng/ml in the diseased group. Thirteen diseased cattle that had developed no obvious neurological signs showed abnormally high S-100B concentrations (> 8.0 ng/ml), whereas the two cattle with neurological disorders did not. No particular disease could be related to the S-100B rise. Therefore, it remains inconclusive whether measurement of CSF S-100B concentration is useful in veterinary neurological diagnosis.