Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
NOTE
Cloning of the Feline GADD45 cDNA and Analysis of its Mutation in Feline Lymphoma Cell Lines
Tatsuo OIKAWAMasaru OKUDANaoki KANEKOMalaika WATANABEHiroko HIRAOKAKazuhito ITAMOTOMunekazu NAKAICHITakuya MIZUNOHisashi INOKUMA
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Keywords: feline, GADD45, P53
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2006 Volume 68 Issue 3 Pages 297-301

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Abstract

Growth arrest and DNA damage-inducible protein 45 (GADD45) plays an important role in suppressing multistep carcinogenesis. In this report, we describe the isolation of the complete wild-type feline GADD45 cDNA from feline tissues. Expression of feline GADD45 mRNA was detected in the liver, spleen, kidney, lung, and testis. The predicted amino acid sequences encoded by the full-length feline GADD45 cDNA display sequence homology with those from other vertebrates, and as in the case of human GADD45, cell growth suppression was observed by ectopic expression of feline GADD45. However, no mutations were detected by sequence analysis of feline GADD45 in several feline lymphoma cell lines, indicating that the GADD45 mutation might be uncommon in feline oncogenesis.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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