Journal of Veterinary Medical Science
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Temporal and Topographic Profiles of Tissue Hypoxia Following Transient Focal Cerebral Ischemia in Rats
Takahisa NOTOYasuhisa FURUICHIMasayuki ISHIYENobuya MATSUOKAIchiro ARAMORISeitaro MUTOHTakehiko YANAGIHARANoboru MANABE
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Volume 68 (2006) Issue 8 Pages 803-807

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Abstract

Intravascular accumulation of blood cells after brain ischemia-reperfusion can cause obstruction of cerebral blood flow and tissue hypoxia/ischemia as a consequence. In the present study, we examined temporal and topographic changes of tissue hypoxia/ischemia after occlusion of the middle cerebral artery (MCA) for 60 min in rats with immunohistochemical staining for hypoxia (2-nitroimidazole hypoxia marker: hypoxyprobe-1 adducts). Our results showed that tissue hypoxia expressed as positive staining for hypoxyprobe-1 adducts preceded neuronal degeneration. Platelets and granulocytes were detected close to the hypoxyprobe-1 adducts positive area. These results suggested that the hypoxic environment could persist even after reperfusion of MCA, because of vascular obstruction with accumulation of platelets and granulocytes.

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    From Vol. 79, No. 1, JVMS became online only with a new one-column layout of full color.

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