Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Surgery
Effects of Intravenous Fentanyl Administration on End-Tidal Sevoflurane Concentrations in Thoroughbred Racehorses undergoing Orthopedic Surgery
Minoru OHTAAi WAKUNOJun OKADAKazumichi KODAIRAShun-ichi NAGATAMotoki ITOKazuomi OKU
著者情報
キーワード: analgesia, fentanyl, racehorse, sevoflurane
ジャーナル フリー

2010 年 72 巻 9 号 p. 1107-1111

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抄録

To evaluate the effects of IV fentanyl administration on the end-tidal sevoflurane concentration (ETSEVO) in thoroughbred racehorses, the ETSEVO required for internal fixation of longitudinal fractures was compared between horses anesthetized with sevoflurane-fentanyl (Group SF; n=9) and those anesthetized with sevoflurane alone (Group S; n=9). The loading dose of fentanyl (5.0 μg/kg) was administered over 15 min followed by a maintenance dose of fentanyl (0.1 μg/kg/min) throughout the operation in Group SF. The mean ETSEVO during the operation in Group SF (2.6 ± 0.2%) was significantly lower than in Group S (3.0 ± 0.3%). The plasma fentanyl concentrations (6.12 ± 0.88 to 7.78 ± 1.12 ng/ml) in 7 out of 9 horses in Group SF were stable and did not change significantly throughout the operation. The mean dobutamine infusion rate required for maintaining a mean arterial blood pressure between 60 and 80 mmHg during the operation in Group SF (0.56 ± 0.30 μg/kg/min) was significantly lower than in Group S (0.90 ± 0.16 μg/kg/min). The qualities of the recoveries were clinically acceptable, and serious complications were not observed in either group. In conclusion, continuous IV fentanyl administration reduced the sevoflurane requirement by 13% in thoroughbred racehorses undergoing orthopedic surgery; however, fentanyl was considered to be less effective in horses compared with other species.

著者関連情報
© 2010 by the Japanese Society of Veterinary Science

この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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