Resveratrol Ameliorates the Oxidative Damage Induced by Arsenic Trioxide in the Feline Lung

抄録

The objective of this study was to evaluate the possible protection of resveratrol against lung injury induced by arsenic trioxide (As₂O₃). Twenty-four healthy Chinese Dragon Li cats of either sex were randomly divided into four groups: control (1 ml/kg physiological saline), As₂O₃ (1 mg/kg), resveratrol (3 mg/kg) and resveratrol (3 mg/kg) + As₂O₃ (1 mg/kg). The resveratrol + As₂O₃- treated group was given resveratrol 1 hr before As₂O₃ (1 mg/kg) administration. We found that pretreatment with resveratrol in a clinically comparable dose regimen can reversed the changes in morphological and biochemical parameters induced by As₂O₃ in the lung. Resveratrol treatment also upregulated the activities of antioxidant enzymes and attenuated As₂O₃-induced increases in reactive oxygen species, 8-hydroxydeoxyguanosine and malondialdehyde production in the lung. In addition, resveratrol attenuated the As₂O₃-induced reduction in the ratio of reduced glutathione to oxidized glutathione, the content of total glutathione and lung arsenic burden. These findings indicated that resveratrol can provide significant protection against As₂O₃-induced oxidative damage.