Shortened Blood Coagulation Times in Genetically Obese Rats and Diet-Induced Obese Mice

Noriyuki KAJI; Dai NAGAKUBO; Shin-ichi HASHIDA; Saya TAKAHASHI; Motoi KURATANI; Norihiko HIRAI; Mitsuyuki SHIRAI; Fumitoshi ASAI

doi:10.1292/jvms.13-0029

Pharmacology

Shortened Blood Coagulation Times in Genetically Obese Rats and Diet-Induced Obese Mice

Noriyuki KAJI, Dai NAGAKUBO, Shin-ichi HASHIDA, Saya TAKAHASHI, Motoi KURATANI, Norihiko HIRAI, Mitsuyuki SHIRAI, Fumitoshi ASAI

著者情報

Noriyuki KAJI
Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
Dai NAGAKUBO
Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
Shin-ichi HASHIDA
Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
Saya TAKAHASHI
Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
Motoi KURATANI
Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
Norihiko HIRAI
Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
Mitsuyuki SHIRAI
Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
Fumitoshi ASAI
Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan

キーワード: blood coagulation time, mouse, obese, rat, visceral fat

ジャーナルフリー

2013 年 75 巻 9 号 p. 1245-1248

DOI https://doi.org/10.1292/jvms.13-0029

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詳細

抄録

The aim of this study was to investigate blood coagulation times in genetically obese rats and diet-induced obese (DIO) mice in order to clarify the relationship between visceral obesity and blood coagulation. WBN/Kob-Lepr^fa (fa/fa) rats, a genetically obese model, exhibited a significantly shorter activated partial thromboplastin time (aPTT) and prothrombin time (PT) than age-matched Wistar rats. C57BL/6J mice fed a high-fat diet (60%), a DIO model, exhibited significantly shorter aPTT, PT and thrombin time than lean mice fed a standard diet. Higher body weight, visceral fat weight and insulin resistance were also shared by fa/fa rats and DIO mice. These results suggest that visceral obesity is related to accelerated blood coagulation in addition to disrupted metabolism of glucose and lipids.

責任著者(Corresponding author)

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