Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
Internal Medicine
Single oral dose safety of D-allulose in dogs
Naohito NISHIIToru NOMIZOSatoshi TAKASHIMATatsuya MATSUBARAMasaaki TOKUDAHitoshi KITAGAWA
著者情報
キーワード: D-allulose, dog, oral dose, rare sugar, safety
ジャーナル フリー

2016 年 78 巻 6 号 p. 1079-1083

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Healthy dogs were administered acute oral doses of D-allulose (also called D-psicose) to evaluate its toxicity. Six dogs received oral doses of either a placebo or D-allulose solution (1 and 4 g/kg) on three different study days. One dog experienced vomiting, and five dogs showed transient diarrhea when 4 g/kg of D-allulose was administered. All dogs were active and had a good appetite throughout the study period. Blood glucose concentration slightly decreased without a rise in plasma insulin concentration 2 hr after D-allulose administration. Plasma alkaline phosphatase activities showed a mild increase between 12 and 48 hr after D-allulose administration. These data suggested that a single oral dose of D-allulose does not show severe toxicity in dogs.

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