Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Virology
Intrauterine infection with bovine leukemia virus in pregnant dam with high viral load
Yamato SAJIKISatoru KONNAIAsami NISHIMORITomohiro OKAGAWANaoya MAEKAWAShinya GOTOMasashi NAGANOJunko KOHARANana KITANOToshihiko TAKAHASHIMotoshi TAJIMAHirohisa MEKATAYoichiro HORIIShiro MURATAKazuhiko OHASHI
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2017 Volume 79 Issue 12 Pages 2036-2039

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Abstract

Enzootic bovine leukemia is caused by the bovine leukemia virus (BLV). BLV is transmitted vertically or horizontally through the transfer of infected cells via direct contact, through milk, insect bites and contaminated iatrogenic procedures. However, we lacked direct evidence of intrauterine infection. The purpose of this study was to confirm intrauterine BLV infection in two pregnant dams with high viral load by cesarean delivery. BLV was detected in cord and placental blood, and the BLV in the newborns showed 100% nucleotide identity with the BLV-env sequence from the dams. Notably, a newborn was seropositive for BLV but had no colostral antibodies. In this study, we presented a direct evidence of intrauterine BLV transmission in pregnant dam with a high proviral load. These results could aid the development of BLV control measures targeting viral load.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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