Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Phase I Dose-Escalation Study of Nimustine in Tumor-Bearing Dogs
Masashi TAKAHASHIYuko GOTO-KOSHINOKenjiro FUKUSHIMAHideyuki KANEMOTOKo NAKASHIMAYasuhito FUJINOKoichi OHNOYasuyuki ENDOHajime TSUJIMOTO
著者情報
キーワード: ACNU, cancer, canine, nitrosourea, phase I
ジャーナル フリー 早期公開

論文ID: 13-0345

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抄録

Nimustine (ACNU) is an alkylating agent of the nitrosourea and can be an antineoplastic agent in dogs. But, there has been no report on its dose-limiting toxicity (DLT) in dogs. This study was a phase I dose-escalation clinical trial to determine the maximum tolerated dose (MTD) and DLT of ACNU in tumor-bearing dogs. The starting dosage was 25 mg/m2, and subsequent dosages were administered in increments of 5 mg/m2 in cohort of 3 dogs. Eight dogs were included and the MTD was determined to be 25 mg/m2, DLT was neutropenia and the optimal interval was considered to be 21 days. The data herein provides a basis for the subsequent phase II trial of ACNU in dogs.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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