Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds

Mohammed ABDEL-HAKIEM; Ayuko YAMASHITA; Ayman ATIBA; Yasuhiko OKAMURA; Masaaki KATAYAMA; Haroun YOUSSEF; Hiroshi ISOMURA; Yuji UZUKA

doi:10.1292/jvms.14-0233

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Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds

Mohammed ABDEL-HAKIEM, Ayuko YAMASHITA, Ayman ATIBA, Yasuhiko OKAMURA, Masaaki KATAYAMA, Haroun YOUSSEF, Hiroshi ISOMURA, Yuji UZUKA

著者情報

キーワード: dachshunds, immunohistochemistry, intervertebral disc (IVD) degeneration, NG2 proteoglycan

ジャーナルフリー早期公開

論文ID: 14-0233

DOI https://doi.org/10.1292/jvms.14-0233

この記事には本公開記事があります。

The final version of this article is now available: Vol. 78 (2016), No. 1 pp. 97-100

詳細

抄録

The pathogenesis of intervertebral disc (IVD) degeneration is not fully understood. The biomolecular signaling pathways involved in the IVD degeneration require further investigation. The aim of this study was to investigate the expression of NG2 proteoglycan in the degenerated IVD. IVD samples were obtained from 16 Dachshunds that were confirmed to have IVD herniation and subsequently underwent hemilaminectomy. The samples were subjected to histological and immunohistochemical (IHC) examination. IHC revealed positive results for the expression of NG2 proteoglycan in all examined samples. The results showed the expression of NG2 proteoglycan by the degenerated IVDs.

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