Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats

Shohei KOBAYASHI; Natsuko KAWANO; Kenji MIYADO; Ryo OHTA; Takahiro AKIMOTO; Taichi HATAKEYAMA; Maiko KAWAGUCHI

doi:10.1292/jvms.21-0046

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Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats

Shohei KOBAYASHI, Natsuko KAWANO, Kenji MIYADO, Ryo OHTA, Takahiro AKIMOTO, Taichi HATAKEYAMA, Maiko KAWAGUCHI

著者情報

Shohei KOBAYASHI
Organization for the Strategic Coordination of Research and Intellectual Property, Meiji University
Lab of Animal Behavior and Environmental Science, School of Agriculture, Meiji University
Natsuko KAWANO
Lab of Regulatory Biology, School of Agriculture, Meiji University
Kenji MIYADO
Department of Reproductive Biology, National Research Institute for Child Health and Development
Ryo OHTA
Hatano Research Institute, Food and Drug Safety Center
Takahiro AKIMOTO
Lab of Animal Behavior and Environmental Science, School of Agriculture, Meiji University
Taichi HATAKEYAMA
Organization for the Strategic Coordination of Research and Intellectual Property, Meiji University
Lab of Animal Behavior and Environmental Science, School of Agriculture, Meiji University
Maiko KAWAGUCHI
Lab of Animal Behavior and Environmental Science, School of Agriculture, Meiji University

キーワード: anti-androgenic substance, computer-assisted sperm analysis, flame retardant, tris(1,3-dichloro-2-propyl) phosphate, sperm

ジャーナルオープンアクセス早期公開

論文ID: 21-0046

DOI https://doi.org/10.1292/jvms.21-0046

この記事には本公開記事があります。

The final version of this article is now available: Vol. 84 (2022), No. 1 pp. 153-156

詳細

抄録

Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is widely used as a flame retardant and is known to exhibit anti-androgenic effects in vitro and in vivo. To assess the reproductive toxicity potency of TDCIPP, we investigated the effects of 7 days of TDCIPP oral administration on epididymal sperm motion and concentration in adult male Wistar–Imamichi rats. Thirty-five days after the final administration, sperm parameters were evaluated by computer-assisted sperm analysis. Results showed that sperm swimming progression and vigor and sperm concentration in TDCIPP-treated rats were unexpectedly higher than those in control rats. TDCIPP did not significantly affect the percentage of motile sperms or sperm swimming pattern. These results contribute to the understanding of the biological effects of TDCIPP.

責任著者(Corresponding author)

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