The profile of urinary lipid metabolites in healthy dogs

Taiki KIDA; Arisa YAMAZAKI; Koji KOBAYASHI; Tatsuro NAKAMURA; Takayuki NAKAGAWA; Ryohei NISHIMURA; Takahisa MURATA

doi:10.1292/jvms.22-0020

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The profile of urinary lipid metabolites in healthy dogs

Taiki KIDA, Arisa YAMAZAKI, Koji KOBAYASHI, Tatsuro NAKAMURA, Takayuki NAKAGAWA, Ryohei NISHIMURA, Takahisa MURATA

著者情報

キーワード: dog, lipid metabolite, urine

ジャーナルオープンアクセス早期公開

論文ID: 22-0020

DOI https://doi.org/10.1292/jvms.22-0020

この記事には本公開記事があります。

The final version of this article is now available: Vol. 84 (2022), No. 5 pp. 644-647

詳細

抄録

Polyunsaturated fatty acids, including arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), are converted to hundreds of lipid mediators by cyclooxygenases (COX), lipoxygenases (LOX), and cytochrome P450 (CYP), or through non-enzymatic processes, and they reflect inflammatory states of the body. We comprehensively analyzed lipid metabolites in dog urine using a liquid chromatograph-mass spectrometry (LC-MS/MS) to describe their metabolic characteristics. We detected 31 AA-derived metabolites, four EPA-derived metabolites, and a DHA-derived metabolite in all urine samples. Among AA-derived metabolites, 15, 5, 3, and 8 were generated by COX, LOX, CYP, and non-enzymatic oxidation respectively. This study will be the first step to use profiles of urinary lipid metabolites for better understanding and diagnosis of canine diseases.

責任著者(Corresponding author)

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