Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Formaldehyde-Fixed Cells Infected with Pseudorabies Virus Conferred Resistance against Aujeszky's Disease
Seiichi TANAKATakashi IMAMURAHajime MATSUIMasashi SAKAGUCHIKazuo MATSUOMichitaka YAMAMOTO
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1994 Volume 56 Issue 6 Pages 1177-1179

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Abstract

Cells infected with Pseudorabies virus (PrV) and fixed with formaldehyde were evaluated as a vaccine against Aujeszky's disease. Mice and pigs inoculated with fixed cells showed no clinical signs. In a challenge test, all fixed cells conferred protection on mice and pigs. Although pigs showed slight symptoms, they were restored to normal health within a few days. These results demonstrate that PrV-infected cells fixed with formaldehyde function as a vaccine against Aujeszky's disease and serve as a novel type of vaccine which is easy to make, and is both safe and effective.

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© The Japanese Society of Veterinary Science
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