Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Mouse Lethal Activity of a HEp-2 Vacuolation Factor, Cereulide, Produced by Bacillus cereus Isolated from Vomiting-Type Food Poisoning
Kunihiro SHINAGAWAYasuteru UENODongliang HUShigeko UEDAShunji SUGII
Author information

1996 Volume 58 Issue 10 Pages 1027-1029


The HEp-2 vacuolation factor (or cereulide) produced by Bacillus cereus isolated from vomiting-type food poisoning, which is supposed to induce emesis, was found to give mouse and suncus lethality after intravenous and intraperitoneal administration. The emetic activity of the factor was also found to be resistant to heating at 121°C for 15 min, exposure to pH 2 and 11, and to digestion with proteolytic enzymes such as pepsin and trypsin. These findings suggest that the cereulide produced by B. cereus is stable in the digestive tracts, induce emesis, and show lethal activity leading to cellular damage.

Information related to the author
© The Japanese Society of Veterinary Science
Previous article Next article