2003 年 23 巻 Supplement2 号 p. 37-40
Hemodynamics plays very important roles on development and growth of intracranial aneurysms, abdominal aortic aneurysms and carotid stenoses. However, there is no well-established in vivo or in vitro hemodynamics measuring system in human vessels at present. Therefore, we established an in vitro simulator for measuring and visualizing hemodynamics in human vessels, characterized by the following items, 1) obtaining multiple 2-dimensional slices including human vessels with the use of a clinical imaging scanner; 2) calculation of 3 dimensional vessel data sets by a computer based on previous clinical data sets; 3) production of a realistic hollow silicon vessel model using previous computer data sets and a three-dimensional printing using powders and adhesive; 4) completion of refraction index matching between the silicon model and a mixture of glycerol and distilled water ; 5) whole field measurement of hemodynamics in the model by using particle image velocimetry. This simulator enabled us to obtain tailor-made hemodynamics in patients' pathological vessels which were as realistic as possible.