KAGAKU KOGAKU RONBUNSHU
Online ISSN : 1349-9203
Print ISSN : 0386-216X
ISSN-L : 0386-216X
Special Issue [Environmental Chemical Engineering: Innovations for the Future Society]
Feasibility of Biodegradation of Clarithromycin by Nitrosomonas europaea
Akihiko TeradaHinako UsuiQian BaoSatoshi NakaiMasaaki Hosomi
Author information
JOURNALS RESTRICTED ACCESS

2017 Volume 43 Issue 4 Pages 264-270

Details
Abstract

Discharge of chemical compounds in pharmaceuticals and personal care products (PPCPs) without appropriate treatment is an environmental problem. Ammonia-oxidizing bacteria (AOB) oxidize ammonia to nitrite and have also been reported to degrade recalcitrant organic compounds by co-metabolism. In this study, Nitrosomonas europaea, a typical ammonia-oxidizing bacterium, was tested against the antibiotic clarithromycin (CAM) and the anticonvulsant carbamazepine (CBZ) and was found to degrade CAM but not CBZ. The pseudo-first-order degradation rate constant of N. europaea for CAM was at maximum one order of magnitude higher than that of activated sludge, showing the feasibility of biodegredation of CAM by N. europaea. Respirometric assay indicated that N. europaea was inhibited at a CAM concentration above 10 µg/L. The microarray for gene expression demonstrated the presence of upregulated genes for ammonia oxidation and ribosome synthesis.

Information related to the author
© 2017 The Society of Chemical Engineers, Japan
Previous article Next article
feedback
Top