KAGAKU KOGAKU RONBUNSHU
Online ISSN : 1349-9203
Print ISSN : 0386-216X
ISSN-L : 0386-216X
Scale-Up of Fermenter: Survey of Industrial Fermenter Specifications
SEI MURAKAMIRYUSEI NAKANOTATSUHIKO MATSUOKA
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JOURNALS FREE ACCESS

2000 Volume 26 Issue 4 Pages 557-562

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Abstract

In order to obtain common specifications for an industry fermenter for scale up reference and new development basis, we have surveyed 480 fermenters which had actually been manufactured. Industrial fermenters of up to hundreds of cubic meters capacity have the following standard specifications; tank height/diameter 1.8; working volume/total volume 0.7; heat transfer area/working volume 5m-1 (1-2m-1 for large scale fermenters); agitation power 6kw/m3 (2kw/m3 for large scale fermenters); impeller spacing/impeller diameter 1.4; impeller diameter/tank diameter 0.38; impeller tip speed 5.5 m/s. Among the surveyed parameters, tank height/diameter and impeller tip speed are in positive correlation with the fermenter scale, and heat transfer area/working volume, agitation power and impeller diameter/tank diameter are in negative correlation. From these relationship analysis, we have obtained a result indicating that scale up has been mostly done by keeping kia constant while sacrificing larger shearing stress caused by higher impeller tip speed.

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© by THE SOCIETY OF CHEMICAL ENGINEERS, JAPAN
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