The Community Spread of Community-Acquired Drug-Resistant Enterobacteriaceae in the Hanshin Area

Abstract

Drug-resistant Enterobacteriaceae are distributed worldwide. In the present study, 1,577 extended spectrum β-lactamse (ESBL)-producing Enterobacteriaceae, 78 carbapenemase-producing Enterobacteriaceae, and 232 carbapenem-resistant Enterobacteriaceae were isolated in 22,241 clinical isolates of Enterobacteriaceae collected from 9 hospitals in the Hanshin area between January 2014 and December 2015. The resulting data were compared with those obtained in an earlier survey, conducted from 2010 to 2011. ESBL-producing Enterobacteriaceae accounted for 7.1% in the 2014-2015 survey, which was a significant increase from 3.5% in the 2010-2011 survey (p＜0.001). ESBL-producing Enterobacteriaceae, carbapenemase-producing Enterobacteriaceae, and carbapenem resistant Enterobacteriaceae were considered to be community-acquired in 23.2%, 12.8%, 11.2% patients, respectively (p＜0.001). Screening for carbapenemase production is important in order to apply appropriate clinical management and infection control measures.