抗HIV薬を個人輸入し予防的に内服と中断を繰り返したことにより高度耐性HIVが検出された1例

抄録

Patients who bypass medical institutions to obtain drugs to treat human immunodeficiency virus (HIV) infections often take the medications irregularly or self-interrupt their own therapy; this is problematic because it leads to drug resistance. In addition, the presence/absence of drug resistance is a determinant of the success of HIV treatment. Thus, testing for drug resistance is essential for initial drug selection.

We present the case of a highly drug-resistant HIV infection in a patient who irregularly took self-prescribed pre-exposure prophylaxis medications (lamivudine/zidovudine/nevirapine). We also showed that dolutegravir and darunavir/ritonavir might be effective as initial therapies in such patients.