1983 Volume 57 Issue 7 Pages 563-569
The appearance of cellular immunity in C57BL/6 germfree mice infected with N. brasiliensis was studied by the delayed hypersensitivity response with picryl chloride and the footpad reaction, and the following results were obtained.
In both the conventional and germfree groups, primary and secondary reactions were observed in the delayed hypersensitivity response due to picryl chloride. There was a pattern of decrease with a peak on the tenth week, thereafter decreasing further with the advancement of age.
The footpad reaction was observed a pattern of retraction of footpad with a peak on the tenth day after the N. brasiliensis infection in both the conventional and germfree groups of mice at the age of three weeks.
The common antigenicity was studied in the induce-antigen by the footpad reaction, finding common antigenicity between the antigen of N brasiliensis and the Salmonella typhimurium.
In comparing the group infected with N. brasiliensis and the conventional group, a stronger footpad swelling was observed in the group infected with N. brasiliensis. However, no swelling was observed in nude mice.