The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospital
The Second Department of Internal Medicine, School of Medicine, Hokkaido University and Related Hospital
The Second Department of Internal Medicine, School of Medicine, Hokkaido University and Related Hospital
The Second Department of Internal Medicine, School of Medicine, Hokkaido University and Related Hospital
The Third Department of Internal Medicine, Hirosaki University School of Medicine and Related Hospital
The First Department of Internal Medicine, Tohoku University School of Medicine
The First Department of Internal Medicine, Tohoku University School of Medicine
Department of Internal Medicine, The Research Institute for Chest Disease and Cancer, Tohoku University
Department of Internal Medicine, The Research Institute for Chest Disease and Cancer, Tohoku University
Department of Internal Medicine, The Research Institute for Chest Disease and Cancer, Tohoku University
Department of Internal Medicine, The Research Institute for Chest Disease and Cancer, Tohoku University
Department of Internal Medicine, The Research Institute for Chest Disease and Cancer, Tohoku University
Department of Internal Medicine, The Research Institute for Chest Disease and Cancer, Tohoku University
Division of Respiratory Disease, Iwaki Kyoritsu General Hospita
Division of Respiratory Disease, Iwaki Kyoritsu General Hospita
Department of Internal Medicine, Kasumigaura National Hospital and Related Hospital
Department of Internal Medicine, Kasumigaura National Hospital and Related Hospital
Department of Internal Medicine, Kasumigaura National Hospital and Related Hospital
Department of Internal Medicine, Kasumigaura National Hospital and Related Hospital
Department of Internal Medicine, Kasumigaura National Hospital and Related Hospital
The Second Department of Internal Medicine, The Jikei University School of Medicine
The Second Department of Internal Medicine, The Jikei University School of Medicine
Department of Internal Medicine, Juntendo University School of Medicine
Department of Internal Medicine, Juntendo University School of Medicine
First Department of Internal Medicine, kyorin University School of Medicine
First Department of Internal Medicine, kyorin University School of Medicine
First Department of Internal Medicine, kyorin University School of Medicine
Department of Internal Medicine, Tokyo Koseinenkin Hospital
Department of Internal Medicine, Tokyo Koseinenkin Hospital
Department of Internal Medicine, Tokyo Koseinenkin Hospital
Infectious Disease Section, Tokyo Metoropolitan Geriatric Hospital
Infectious Disease Section, Tokyo Metoropolitan Geriatric Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Chest Medicine, National Medical Center Hospital
Department of Chest Medicine, National Medical Center Hospital
Chest Clinic, Toranomon Hospital
Chest Clinic, Toranomon Hospital
Chest Clinic, Toranomon Hospital
Chest Clinic, Toranomon Hospital
Chest Clinic, Toranomon Hospital
Chest Clinic, Toranomon Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Yokohama Teishin Hospital
Department of Infectious Desease, Kanagawa Prefectural Nursing and Hygienic School Hospital
Department of Chest, Kanagawa Prefectural Nagahama Hospital
Department of Chest, Kanagawa Prefectural Nagahama Hospital
Department of Chest, Kanagawa Prefectural Nagahama Hospital
Department of Chest, Kanagawa Prefectural Nagahama Hospital
Department of Chest, Kanagawa Prefectural Nagahama Hospital
Department of Internal Medicine (II), Niigata University, School of Medicine
Department of Internal Medicine, Shinrakuen Hospital
Department of Internal Medicine, Shinrakuen Hospital
Department of Internal Medicine, Suibarago Hospital
Department of Internal Medicine, Toyama Prefectural Central Hospital
First Department of Internal Medicine, Nagoya City University Medical School andRelated Hospital
First Department of Internal Medicine, Nagoya City University Medical School andRelated Hospital
First Department of Internal Medicine, Nagoya City University Medical School andRelated Hospital
First Department of Internal Medicine, Nagoya City University Medical School andRelated Hospital
Chest Disease Research Institute, Kyoto University First Department of Internal Medicine
Chest Disease Research Institute, Kyoto University First Department of Internal Medicine
Chest Disease Research Institute, Kyoto University First Department of Internal Medicine
Chest Disease Research Institute, Kyoto University First Department of Internal Medicine
Sceond Department of Internal Medicine, Nara Medical University
Sceond Department of Internal Medicine, Nara Medical University
Sceond Department of Internal Medicine, Nara Medical University
Sceond Department of Internal Medicine, Nara Medical University
Sceond Department of Internal Medicine, Nara Medical University
Sceond Department of Internal Medicine, Nara Medical University
Department of Internal Medicine, Tane General Hospital
First Department of Internal Medicine, Kansai Medical University and Related Hospital
First Department of Internal Medicine, Kansai Medical University and Related Hospital
First Department of Internal Medicine, Kansai Medical University and Related Hospital
Department of Internal Medicine, Izumi City Hospital
Division of Respiratory Diseases, Department of Internal Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Internal Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Internal Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Internal Medicine, Kawasaki Medical School
Second Department of Internal Medicine, Hiroshima University School of Medicine
Second Department of Internal Medicine, Hiroshima University School of Medicine
Second Department of Internal Medicine, Hiroshima University School of Medicine
Department of Internal Medicine, Funairi Hiroshima City Hospital
Department of Internal Medicine, Kure National Hospital
Department of Internal Medicine, Kure National Hospital
Department of Internal Medicine, Kure National Hospital
The 3rd Department of Internal Medicine, Tokushima University, School of Medicine
The 3rd Department of Internal Medicine, Tokushima University, School of Medicine
The 3rd Department of Internal Medicine, Tokushima University, School of Medicine
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University School of Health Sciences, Kyushu University
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University School of Health Sciences, Kyushu University
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University School of Health Sciences, Kyushu University
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
The First Department of Internal Medicine, Kumamoto University Medical School
The First Department of Internal Medicine, Kumamoto University Medical School
The First Department of Internal Medicine, Kumamoto University Medical School
The First Department of Internal Medicine, Kumamoto University Medical School
Department of Internal Medicine, Kumamoto City Hospita
Department of Internal Medicine, Kumamoto City Hospita
Department of Internal Medicine, Kumamoto City Hospita
Second Department of Internal Medicine, Medical College of oita
Second Department of Internal Medicine, Medical College of oita
Second Department of Internal Medicine, Medical College of oita
Second Department of Internal Medicine, Medical College of oita
First Department of Internal Medicine, School of Medicine, University of the Ryukyus
First Department of Internal Medicine, School of Medicine, University of the Ryukyus
First Department of Internal Medicine, School of Medicine, University of the Ryukyus
1984 Volume 58 Issue 10 Pages 1046-1072
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The clinical efficacy and safety of Enoxacin (AT-2266, ENX) were compared with those of cefaclor (CCL) in 188 patients with chronic respiratory tract infections (chronic RTI) and those with exacerbated acute infections by a double-blind study at 40 institutions in Japan. Patients over 16 years old with apparent clinical signs and symptoms were administered ENX or CCL orally for 14 days at a daily dose of 3 tablets or capsules (ENX: on tablet contains 200 mg of ENX; CCL: on capsule contains 250 mg of CCL). The parameters assessed were clinical efficacy, bacteriological response, rate of improvement of clinical signs and symptoms, appearance of side effect, abnormal loboratory findings and clinical usefulness.
1. Clinical efficacy was analysed statistically 166 patients (88 administered ENX., 78 administered CCL) and 22 patients out of a total of 188 patients were excluded. Side effects were also analysed in 179 patients (ENX: 96, CCL 83) in whom judgement was possible.
2. On the basis of committee judgement the overall clinical efficacy rates for all the cases were 56.8% for ENX and 62.8% for CCL, those for chronic RTI were 56.3% for ENX and 62.7% for CCL. No significant difference was observed between the two drug groups.
In the evaluation of clinical efficacy by the doctor, the overall efficacy ratesin all the cases were 56.8% for ENX and 55.1% for CCL, those for chronic RTI were 56.3% for ENX and 56.0% for CCL. No significant difference was observed between the two drug groups.
3. The bacteriological eradicated rate of causative organisms was 54.2% out of 48 patients treated with ENX and 50.9% out of 60 treated with CCL and there was no significant differences between the two groups. At showed an eradication rate of 18.2% in S. pneumoniae and that of 84.6% in H influenzae, while the corresponding rates for CCL were 71.4% in S. pneumoniae and 63.2% in H.influenzae. The ENX group was superior to the CCL group in the bacteriological response in H influenzae among causative organisms (p<0.10) and the CCL group was superior to the ENX group in S. pneumoniae (p<0.05).
4. With respect to the rate of improvement of clinical signs and symptoms the ENX group was superior to the CCL group in the improvement for sputum volume five days after treatment (p<0.05).
5. The incidence of side effects was 11.5% for ENX and 2.4% for CCL. The ENX group displayed significantly higher rate of side effects than the CCL group. Abnormal laboratory findings were observed at the rate of 19.7% for ENX and 14.1% for CC1, without significant differences between the two groups.
6. Regarding usefulness as judged by committtee members the respective rate for the ENX group and CCL group were 53.3% and 62.8% and usefulnss as judged by the doctor in charge those were 45.7% for ENX and 48.7% for CCL. These assessements showed no significant differences between the two.
From the above results it was concluded that ENX is an equal useful drug to CCL for the treatment of chronic RTI caused by gram negative bacteria.