Clinical Studies on DL-8280 in Male Gonococcal Urethritis
1984 Volume 58 Issue 8 Pages 784-789
Details
1984 Volume 58 Issue 8 Pages 784-789
Clinical effect of DL-8280, a new oral antimicrobial agent, was investigatect against z4 patients with male gonococcal urethritis.
The patients consisted of age distribution between 21 and 55 years. The dose was 200 mg b. i. d. and the duration of administration was 5 or 6 consecutive days.
Clinical effect obtained was excellent in 20 cases and good in 4 cases, and clinical efficacy rate was 100%. As side effect, 1 case of rash was observed but the medication could be continued. Slightly abnormal laboratory findings were observed in 6 cases, however they were not considered to be due to DL-8280.
MIC of DL-8280 against clinically isolated N. gonorrhoeae was distributed between ≤ 0.006 and 0.20μg/ml. And its MIC was superior to that of NFLX, ABPC and PCG.
