Kansenshogaku Zasshi
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
Phagocytosis and Intracellular Killing of Pseudomonas aeruginosa by Activated Macrophages
In Comparison with Staphylococcus aureus and Latex Particles
Akiko SAKURAINobuko SATOMIKatsuyuki HARANAKAOtohiko KUNII
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1985 Volume 59 Issue 6 Pages 597-604

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Abstract

The roles of oxidative metabolism and lysosomal enzymes in the phagocytosis of activated macrophages against Pseudomonas aeruginosa, Staphylococcus aureus, and latex particles were studied. It can be said that enhancement of the host defence mechanism against p. aeruginosa infection was increased by activating the reticuloendothelial system by Propionibacterium acnes pretreatment. The oxidative metabolism as measured from cheniluminescence, and lysosomal enzymes against p. aeruginosa play an important role in the intracellular killing of bacteria, and these activities are enhanced by p.acnes treatment. Activated macrophages generated the highest chemiluminescence response when they ingested p.aeruginosa in combination with gentamicin and gamma-globulin. In contrast, such mechanisms show little participation against S. aureus and latex particles.

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© The Japansese Association for Infectious Diseases
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