1985 Volume 59 Issue 9 Pages 921-934
During 1.5 months starting from late April through early June in 1983, we have isolated hemolytic streptococci group-A (413 strains), group-B (197 strains), group-C (12 strains) and group-G (63 strains) from throats of elementary and junior high school pupils in 7 prefectures as described in the Part I and tested their susceptibility to antibiotics.
1. Penicillins: In general, benzyl penicillin (PCG) was the most effective among PCG, ampicillin (ABPC) and amoxicillin (AMPC), and sulbenicillin (SBPC) was the least effective.The group-B was less susceptible than the group-A to penicillins.
2. Cephems: Cephaloridine (CER) was the most effective, followed by cephalothin (CET), and latamoxef (LMOX) was the the least effective among cephems.The group-B streptococci was the most resistant to cephems as well as PCG, and a strain resistant to LMOX (MIC25μg/ml) was isolated.
3.Macrolides: Erythromycin (EM) was effective among EM, oleandomycin (OL) and josamycin (JM).The group-A streptococci resistant or highly resistant (MIC 100-≥200μg/ml) to EM, OL and JM were found in 6.7, 8.7 and 8.5%, or in 5.8, 4.6and5.8% of the isolated strains, respectively. Strains highly resistant to OL or resistant to EM and JM were found in group-B.
4.Tetracyclin (TC): Resistance to TC varied among group-A, B and G streptococci, showing a biphasic resistant pattern.Strains resistant and highly resistant to TC were found in the above 3 groups, but not in group-C.
5.Chloramphenicol (CP): Strains resistant and highly resistant to CP were found in group-A and -B.
6.Comparison of microbial susceptibility to antibiotics among T types. Strains resistant and highly resistant to EM, OL and JM were found frequently in many of T-12type and in one of T-11 type. Strain resistant or highly resistant to TC was found in T-1, T-3, T-4, T-12, T-13, and T-28 types, or in T-4 and T-12 types, respectively. Strain resistant or highly resistant to CP was found in T-11 and T-12 types, respectively.
7. Comparison of strains resistant to TC, CP and macrolide antibiotics from standpoint of types.
Strain resistant to TC, CP and macrolide was found in many of T-12 type and in one of T-11 type of group A, and one of III type of group B. Strain resistant only to macrolide was found in Ic and Ia types of group B, and in none of group A. Strain resistant only to TC was found in many, especially of T-13, T-12 and T-4 types. Strain resistant only to CP or to both TC and CP was few.
8.Regional comparison of detection rate of strains resistant to antibiotics.T-12 type strain resistant to antibiotics was frequently found in Akita and Osaka but less frequently in Shimane.Strains resistant only to macrolide were found frequently in the north region and less frequently in the south regions.
