1986 Volume 60 Issue 10 Pages 1160-1164
A case of acute myelogenous leukemia complicated with multiple liver abscesses by Candida albicans was reported. The patient was a 46-year-old Japanese woman, who was referred to Kyushu University Hospital because of severe anemia. Before admission, she was transfused more than 1, 000 ml of packed red blood cells in total. On admission, the number of bone marrow nucleated cells was 38 × 104/mm3, and 91% of them were peroxidase positive myeloblasts. During the course of remission inductiontherapy with BH-AC, daunorubicin, 6-mercaptopurine and prednisolone, she developed high fever which was unresponsive to various kinds of antibiotics. Twenty days after the onset of high fever, ultrasound tomography revealed multiple “bull's eye” lesions in the liver. Multiple liver abscesses were demonstrated by abdominal CT. Culture of the aspirate demonstrated Candida albicans in the lesion. Treatment with Amphotericin B of a total dose of 3800 mg for more than six monthsand drainage of some abscesses were ineffective. Eight months after her admission, acute myelogenous leukemia relapsed.
