Clinical Features, Laboratory Data and Anti-Viral Antibody Titers in a Severe Case of Hemorrhagic Fever with Renal Syndrome (HFRS)-One-Month Course from the Onset

Abstract

A medical staff of Osaka University Hospital (31-year-old male) was admitted to our department because of hemorrhagic fever with renal syndrome (HFRS) in November, 1984. He only visited an animal laboratory two weeks before the onset of fever but touched neither animalsnor their discharges. His laboratory data were first obtained on the day of onset of fever and followedalmost daily throughout one-month hospitalization. The clinical examinations demonstrated the deveropmentof disseminated intravascular coagulation syndrome (DIC), hepatic, renal and cardiac damages withelectrolyte and metabolic disorders. This is the first HFRS case in whom urinary β₂-microglobulin and N-acetyl-β, Dglucosaminidase, isoenzyme patterns of serum LDH and CPK were examined.
Titers of serum antibody to HFRS viruses (both Hantaan 76-118 and B-1 strain) were measured by indirect fluorescent antibody (IF) and hemagglutination inhibition (HI) tests throughout the course. The titers obtained by these two methods were changed in parallel, but IF test was proved to be more sensitive and useful for earlier diagnosis of HFRS. The titer of antibody to B-1 strain measured by IF test was elevated to 1: 128 on the third day from the onset and reached maximum levels of 1: 32, 000-64, 000 after two weeks.