1987 Volume 61 Issue 12 Pages 1382-1394
The studies on combination therapy of norfloxacin (NFLX) and fosfomycin (FOM) were performed, and following results were obtained.
1. The fractional inhibitory concentration index (FTC index)≤0.5 between NFLX and FOM showed 76.5%(26/34) against P. aeruginosa isolated from respiratory patients for respiratory tract infection and 60.9%(14/23) against methicillin resistance S. aureus.
The synegistic effect was confirmed in this in vitro study.
2. The FIC index derived from the combination therapy was 0.06 agaisnt one strain of P. aeruginosa shown MIC of 100μg/ml in NFLX and MIC of 600μg/ml in FOM.
3. Clinical effect was good in 15 cases (93.8%) and fair one case (6.2%).
4. Bacteriologically 24 strains out of 25 strains isolated from 16 patients were eradicated after the treatment; 8/9 in P.aeruginosa, 6/6 in H.influenzae, 6/6 in S.aureus, 1/1 in S.pneumoniae, 1/1 in S.pyogenes, 1/1 in K.pneumoniae and 1/1 in Flavobacterium sp.
5. No adverse effect and abnormal labolatory findings were observed in this study.
It is suggested that the combination of NFLX and FOM is useful for the treatment of respiratory tract infections.
