1988 Volume 62 Issue 11 Pages 959-966
In recent years, there has been an increase of deep mycoses in the patients with a compromised host. We examined clinicopathologically deep mycoses out of 182 autopsied cases experienced in our department from 1981 to 1987, and results obtained are as follows:
The incidence of pulmonary mycoses was 23.1% and it was higher in hematologic malignancies (42.3%) than solid ones (8.9%). The common mycoses were aspergillosis and candidiasis which were observed in 18 and 15 cases respectively, followed by mixed mycosis in 6, cryptococcosis in 2 and mucormycosis in one. Most of the patients received large doses of antimicrobial drugs, anticancer drugs and corticosteroids, and showed marked granulocytopenia and lymphocytopenia.
It is suggested that the host defence mechanism against deep mycoses chiefly depend on granulocyte counts and function, and cellular immunity.
