1989 Volume 63 Issue 10 Pages 1165-1170
Effects of oral aztreonam on fecal flora were studied in 6 comporomised children. Their ages ranged from 4 to 14 years. Daily doses of aztreonam were 10 to 30 mg/kg. The stool specimens were obtained before the treatment, on day 5 to 7 of aztreonam use and 2 to 5 days after the cessation of treatment.
The counts of enterobacteria decreased from 107.7 to 104.4 per gram of wet feces (p<0.01), and bifidobacteria also decreased from 1010.2 to 108.4 per gram of wet feces (p<0.01) during aztreonam administration. Those of streptococci increased from 102.9 to 109.4 per gram of wet feces (p<0.001). The other anaerobic organisms showed no marked change.
Based upon the above results, we conclude that oral administration of aztreonam may be useful for selective decontamination of intestinal flora in compromised hosts.