In Vitro Effect of Menfegol on Neisseria gonorrhoeae

Abstract

Bacteriostatic and bactericidal effect of Menfegol, which has been used as a spermicide, on Neisseria gonorrhoeae was investigated in vitro. The distribution of the MICs of N. gonorrhoeae to Menfegol consisted of 2 groups. Resistant strains showed the MICs of more than 3200 & mu;g/ml while the MICs of sensitive strains were less than or equal to 200 & mu;g/ml. When the resistant strains were suspended in several concentrations of Menfegol and were incubated at 35 & deg;C, no concentrations inactivated gonococci completely. However, the number of organisms was remarkably decreased within 30 minutes.