Kansenshogaku Zasshi
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
Antigen Detection in the Murine Models of Systemic Candidiasis
Kotaro MITSUTAKEShigeru KOHNOHaruko MATSUDAYuko YOSHITOMIYoshitsugu MIYAZAKIYasuhito HIGASHIYAMAKen-ichi TANAKAMasanori IWAMOTOShigefumi MAESAKIMitsuo KAKUHironobu KOGAKohei HARA
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1992 Volume 66 Issue 6 Pages 716-720

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Abstract

We compared two latex agglutination tests for serum candidal antigen in murine models of systemic infection and gastrointestinal colonization. In the intravascular-infection model, mannan detection test was positive at 2 hours after inoculation, but Cand-Tec was less sensitive than mannan detection test in this model.
In the gastrointestinal colonization model followed by systemic infection in neutropenic mice, the mannan antigen test became positive after 3 weeks of colonization with increased number of Candida of the stool, and Cand-Tec became positive after 5 weeks in neutropenic mice.

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© The Japansese Association for Infectious Diseases
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