Four Cases of Hemolytic Uremic Syndrome (HUS) Associated with Serotype O165 Verotoxin Producing Escherichia coli (VTEC) Identified by LPS-solid Phase Enzyme-Linked Immunosorbent Assay (ELISA)

Abstract

Enzyme-linked immunosorbent assay using LPS derived from newly recognized serotype O 165 verotoxin producing Escherichia coli (VTEC) could identify 4 cases of hemolytic uremic syndrome (HUS) associated with 0165 VTEC. All 4 cases showed a typical clinical course seen in VTEC-associated HUS. We screened 33 cases of HUS whose pathogen was not identified by culture or serodiagnosis. The O165 serotype was not thought to be important not only as a VTEC but also as an enteropathogenic E. coli. However, the prevalence, 4 cases, was as high as of O111 serotype, which is the seond major serotype of VTEC in Japan. We have to be careful for this serotype when we look for the pathogen of the patients with hemorrhagic colitis or with HUS.