Kansenshogaku Zasshi
Online ISSN : 1884-569X
Print ISSN : 0387-5911
Varicella-zoster Virus Symptoms and Polyneuropathy in a Patient with Human Immunodeficiency Virus Infection Not Improved until Highly Active Anti-retroviral Therapy Added to Acyclovir Therapy
Hiroaki TAKEOKAYong CHONGMasayuki MURATANorihiro FURUSYOShigeki NABESHIMAKouzaburo YAMAJIYasuhiro KISHIHARAJun HAYASHI
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2006 Volume 80 Issue 1 Pages 46-50

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Abstract

In March 2003, a 34-year-old man with left facial palsy, dysphagia, and hoarsenesstreated with acyclovir suffered worsened dermatological and neurological problems. A routine blood test in early April showed the patient to be HIV-antibody positive, so he was transferred to our hospital. Blood analysis showed serum HIV-RNA at 96, 000 copies/mL and a CD 4 count of 170/μL. Brain MRI taken on admission showed a T 2 high lesion in their left medulla. Acyclovir was thought to be ineffective due to reduced cellmediated immunity because of the HIV infection, and HAART therapy was begun. After two months of HAART, skin lesions and the T 2 high lesion in left medulla improred. HIV-RNA became undetectable and the CD 4 count exceeded 500/μL. lntracellular cytokine analysis by flow cytometry showed a shift from Th 2 to Th 1 dominance. The elimination of VZV may thus have been promoted by the combination of acyclovir and HAART.

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© The Japansese Association for Infectious Diseases
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