肝臓
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
速報
劇症E型肝炎:"Kitami/Abashiri strain"が検出された第3例目
菅原 伸明矢和田 敦高橋 和明安倍 夏生新井 雅裕
著者情報
ジャーナル フリー

2009 年 50 巻 8 号 p. 473-474

詳細
抄録

A 60 years old man died of fulminant hepatitis E on 21st April, 2009, in Hakodate, Hokkaido, Japan. The hepatitis E virus (HEV) genomic sequence from this patient segregated to genotype 4, which is known to be more pathogenic than genotype 3 and more prevalent in Hokkaido than in other areas of Japan. To our surprise, however, this HEV isolate co-clustered with the so-called "Kitami/Abashiri strain", which had been recovered from fulminant hepatitis patients in Kitami and Abashiri (also Hokkaido) in 2004 and 2006, respectively. Thus, an apparent association of this lineage of HEV with fulminant hepatitis has been observed 3 times, leading us to suspect a causal relationship. Most likely this HEV lineage is being passaged/propagated in pig farm (s) somewhere in Hokkaido, and may cause another case(s) of severe hepatitis unless countermeasures are taken.

著者関連情報
© 2009 一般社団法人 日本肝臓学会
前の記事 次の記事
feedback
Top